Smith Stephen M
Saint Michael's Medical Center and The New Jersey Medical School, Newark New Jersey 07102, USA.
Retrovirology. 2006 Sep 8;3:60. doi: 10.1186/1742-4690-3-60.
In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4+ T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4+ T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.
在20世纪90年代中期，研究人员根据新的病毒载量数据推测，HIV-1通过直接细胞病变效应导致CD4+ T细胞耗竭。来自非人类灵长类动物研究的新数据对这种HIV-1发病机制模型提出了质疑。尽管病毒血症水平很高，但大多数SIV感染在其自然宿主中耐受性良好。最近对这些模型的两项研究提供了信息，这可能有助于确定HIV-1如何导致CD4+ T细胞损失。对发病机制的全面理解可能会带来新的疗法，既能保护免疫系统又不阻断病毒复制。
