Su Michael W, Fromer Eric, Fung Maxwell A
University of California Davis, Department of Dermatology, USA.
Dermatol Online J. 2006 Sep 8;12(5):2.
An 88-year-old woman presented with an 8-year history of a slowly enlarging growth on the suprapubic area. A shave excision of this lesion demonstrated fibroepithelioma of Pinkus (FEP). Fibroepithelioma of Pinkus is an indolent growing tumor that traditionally has been classified as a variant of the basal cell carcinoma. More recent evidence favors the classification of FEP as a variant of trichoblastoma. In this case report, we identified a large FEP with benign histologic features suggestive of a follicular origin as demonstrated in part by CK 20 staining and the presence of scattered Merkel cells within the tumor. The pathogenesis of FEP remains enigmatic, and the genetic basis has yet to be fully elucidated. Complete surgical resection is considered curative.
一名88岁女性,耻骨上区有一缓慢增大的肿物,病史8年。对该病变进行削切活检,结果显示为平卡斯纤维上皮瘤(FEP)。平卡斯纤维上皮瘤是一种生长缓慢的肿瘤,传统上被归类为基底细胞癌的一种变体。最近的证据支持将FEP归类为毛母细胞瘤的一种变体。在本病例报告中,我们发现了一个具有良性组织学特征的大型FEP,提示其起源于毛囊,部分表现为细胞角蛋白20(CK 20)染色阳性以及肿瘤内散在的默克尔细胞。FEP的发病机制仍然不明,其遗传基础尚未完全阐明。完整的手术切除被认为可治愈。