Tarallo M, Cigna E, Fino P, Lo Torto F, Corrias F, Scuderi N
Department of Dermatology and Plastic, Reconstructive and Aesthetic Surgery, Sapienza, University of Rome, Italy.
G Chir. 2011 Jun-Jul;32(6-7):326-8.
Fibroepithelioma of Pinkus (FeP) is a rare tumor that most often affects women aged between 40 and 60 years. Clinically FeP presents as a soft, usually solitary, polypoid or papillomatous well circumscribed tumor of skin color. It is typically located to the trunk and extremities.
A 75 year old male presented to our Department complaining for the presence of a lesion of the dorsal region. His medical history was free except for several basal cell carcinoma (BCC) surgically excised. Clinical examination revealed a pigmented lesion in the back. The lesion was surgically excised and histopathology showed of a fibroepithelioma of Pinkus.
Currently, FeP is considered a rare variant of basal cell carcinoma, with characteristic histopathological features, although this view is somewhat controversial as some authors considered FeP to be a variant of trichoblastoma. The pathogenesis of FeP is still under investigation. It is thought that a mutation in the tumor suppressor gene TP53 might predispose to the development of FeP.
Our case is interesting for two reasons. First, in our case FeP is pigmented. Moreover we present a case of Fep in a patient with a history of BCC, a finding that supports the classification of fibroepithelioma of Pinkus as a variant of basal cell carcinoma.
平卡斯纤维上皮瘤（FeP）是一种罕见肿瘤，最常发生于40至60岁的女性。临床上，FeP表现为一个柔软的、通常为孤立的、息肉样或乳头状的、边界清楚的肤色肿瘤。它通常位于躯干和四肢。
一名75岁男性因背部出现病变前来我院就诊。除了手术切除的几例基底细胞癌（BCC）外，他的病史无异常。临床检查发现背部有一个色素沉着病变。该病变经手术切除，组织病理学显示为平卡斯纤维上皮瘤。
目前，FeP被认为是基底细胞癌的一种罕见变体，具有特征性的组织病理学特征，尽管这种观点存在一定争议，因为一些作者认为FeP是毛母细胞瘤的一种变体。FeP的发病机制仍在研究中。据认为，肿瘤抑制基因TP53的突变可能易导致FeP的发生。
我们的病例有两个有趣之处。首先，在我们的病例中FeP是色素沉着的。此外，我们报告了一例有BCC病史患者的FeP病例，这一发现支持将平卡斯纤维上皮瘤归类为基底细胞癌的一种变体。
