Sivamani Raja, Wadhera Akhil, Craig Errol
University of California Davis, Department of Dermatology, USA.
Dermatol Online J. 2006 Sep 8;12(5):8.
An 84-year-old man presented with an enlarging bluish, painless subcutaneous nodule on the glabella. The lesion had been excised 4 years prior and was diagnosed as chondroid syringoma, but had gradually regrown. The recurrent lesion was treated by surgical re-excision. Histopathological examination was again consistent with chondroid syringoma, and showed the following: 1) a chondroid matrix, 2) tubuloalveolar structures lined by a double epithelium, 3) ductal structures lined by a single epithelium, 4) nests of polygonal cells, and 5) the presence of keratinous cysts. Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig. Characteristically, it is composed of a proliferation of epithelial cells set in a myxoid and chondroid matrix. Although chondroid syringomas are predominantly benign, malignant forms have been reported.
一名84岁男性患者,眉间出现一个不断增大的蓝色无痛性皮下结节。该病变4年前曾行切除,诊断为软骨样汗管瘤,但后来逐渐复发。复发病变通过再次手术切除进行治疗。组织病理学检查结果再次符合软骨样汗管瘤,表现如下:1)软骨样基质;2)由双层上皮衬里的小管状腺泡结构;3)由单层上皮衬里的导管结构;4)多边形细胞巢;5)角质囊肿的存在。软骨样汗管瘤是一种罕见的皮肤混合瘤,最初由赫希和赫尔维格描述。其特征是由在黏液样和软骨样基质中增生的上皮细胞组成。虽然软骨样汗管瘤主要为良性,但也有恶性形式的报道。