Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Faculty of Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.
Int J Mol Sci. 2021 May 11;22(10):5077. doi: 10.3390/ijms22105077.
Adnexal tumors of the skin are a rare group of benign and malignant neoplasms that exhibit morphological differentiation toward one or more of the adnexal epithelium types present in normal skin. Tumors deriving from apocrine or eccrine glands are highly heterogeneous and represent various histological entities. Macroscopic and dermatoscopic features of these tumors are unspecific; therefore, a specialized pathological examination is required to correctly diagnose patients. Limited treatment guidelines of adnexal tumor cases are available; thus, therapy is still challenging. Patients should be referred to high-volume skin cancer centers to receive an appropriate multidisciplinary treatment, affecting their outcome. The purpose of this review is to summarize currently available data on pathogenesis, diagnosis, and treatment approach for apocrine and eccrine tumors.
皮肤附件肿瘤是一组罕见的良性和恶性肿瘤，其形态分化为正常皮肤中存在的一种或多种附件上皮类型。来源于顶泌汗腺或小汗腺的肿瘤具有高度异质性，代表各种组织学实体。这些肿瘤的宏观和皮肤镜特征是不特异的；因此，需要进行专门的病理检查才能正确诊断患者。目前可获得的皮肤附件肿瘤病例的治疗指南有限；因此，治疗仍然具有挑战性。患者应转至大容量皮肤癌中心接受适当的多学科治疗，这会影响他们的治疗效果。本文综述了目前关于顶泌汗腺和小汗腺肿瘤的发病机制、诊断和治疗方法的相关数据。
