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Immunodominant epitopes of the adhesin of Mycoplasma pneumoniae.肺炎支原体黏附素的免疫显性表位
J Clin Microbiol. 1990 Jun;28(6):1194-7. doi: 10.1128/jcm.28.6.1194-1197.1990.
2
Molecular mimicry by Mycoplasma pneumoniae to evade the induction of adherence inhibiting antibodies.肺炎支原体通过分子模拟来逃避诱导黏附抑制抗体。
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本文引用的文献

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Application of a microtechnique to viral serological investigations.一种微技术在病毒血清学研究中的应用。
J Immunol. 1962 Mar;88:320-9.
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Mycoplasma pneumoniae adhesin localized to tip structure by monoclonal antibody.肺炎支原体黏附素通过单克隆抗体定位于顶端结构。
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Molecular basis for cytadsorption of Mycoplasma pneumoniae.肺炎支原体细胞吸附的分子基础。
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Mycoplasma pneumoniae infection: role of a surface protein in the attachment organelle.肺炎支原体感染：一种表面蛋白在附着细胞器中的作用
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Prediction of protein antigenic determinants from amino acid sequences.从氨基酸序列预测蛋白质抗原决定簇。
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Tissue cultures and mycoplasmas.组织培养与支原体。
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Antibodies in the sera of Mycoplasma pneumoniae-infected patients against proteins of Mycoplasma genitalium and other mycoplasmas of man.肺炎支原体感染患者血清中针对生殖支原体及其他人类支原体蛋白质的抗体。
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10
Isolation of the adherence protein of Mycoplasma pneumoniae by fractionated solubilization and size exclusion chromatography.通过分级溶解和尺寸排阻色谱法分离肺炎支原体的黏附蛋白。
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肺炎支原体黏附素的免疫显性表位

Immunodominant epitopes of the adhesin of Mycoplasma pneumoniae.

作者信息

Jacobs E, Pilatschek A, Gerstenecker B, Oberle K, Bredt W

机构信息

Institute for Medical Microbiology and Hygiene, University of Freiburg, Federal Republic of Germany.

出版信息

J Clin Microbiol. 1990 Jun;28(6):1194-7. doi: 10.1128/jcm.28.6.1194-1197.1990.

DOI:10.1128/jcm.28.6.1194-1197.1990
PMID:1696281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC267904/
Abstract

Overlapping octapeptides from the amino acid sequence of the adherence protein of Mycoplasma pneumoniae were synthesized and used as the antigen in an enzyme-linked immunosorbent assay with serum samples from M. pneumoniae-infected patients. Of a sequence of 338 amino acids positioned between leucine 801 and leucine 1139, only two regions with immunodominant continuous epitopes were detected. The immunoglobulin G and immunoglobulin M antibodies of child and adult patients reacted especially with the NH2-(810)-W-I-G-N-G-Y-R-Y peptide but also reacted with the NH2-(1124)-F-T-D-F-V-K-P-R peptide.

摘要

合成了来自肺炎支原体黏附蛋白氨基酸序列的重叠八肽，并将其用作酶联免疫吸附测定中的抗原，检测肺炎支原体感染患者血清样本。在位于亮氨酸801和亮氨酸1139之间的338个氨基酸序列中，仅检测到两个具有免疫显性连续表位的区域。儿童和成年患者的免疫球蛋白G和免疫球蛋白M抗体尤其与NH2-(810)-W-I-G-N-G-Y-R-Y肽发生反应，但也与NH2-(1124)-F-T-D-F-V-K-P-R肽发生反应。