Samuelsson U, Carstensen J, Löfman O, Nordfeldt S
Division of Paediatrics, Department of Molecular and Clinical Medicine, Linköping University, S-581 85 Linköping, Sweden.
Diabetes Res Clin Pract. 2007 Apr;76(1):75-81. doi: 10.1016/j.diabres.2006.07.023. Epub 2006 Sep 11.
With the aim to survey the seasonal pattern of diagnosis of type 1 diabetes we included all 1903 children <16 years of age and who had been diagnosed with type 1 diabetes between 1977 and 2001 in the south-east of Sweden. To investigate the seasonal pattern a mixture of two cosine functions was included in a logistic regression model. There was a clear seasonal variation over the years (p<0.001). Children in the oldest age group (11-15 years) showed the most obvious seasonal variation (p<0.001). Children with a short duration of symptoms had about the same seasonal variation as children with a long duration. Both children with and without an infection 3 months prior to diagnosis showed significant seasonal variation (p<0.001) although the seasonal pattern differed between the two groups (p<0.001). As the incidence of diabetes increased during the 25 years the study period was divided into periods of 5 years and it was only during the two last periods that significant seasonal variation occurred. There is a clear seasonal variation in diagnosis of type 1 diagnosis in children and the results suggest that children with a less aggressive disease process at diagnosis were most responsible for this variation. Children with and without prior infection showed a different seasonal pattern.
为了调查1型糖尿病的诊断季节模式，我们纳入了瑞典东南部所有1903名年龄小于16岁且在1977年至2001年间被诊断为1型糖尿病的儿童。为了研究季节模式，在逻辑回归模型中纳入了两个余弦函数的混合模型。多年来存在明显的季节变化（p<0.001）。年龄最大的年龄组（11 - 15岁）的儿童表现出最明显的季节变化（p<0.001）。症状持续时间短的儿童与症状持续时间长的儿童具有大致相同的季节变化。诊断前3个月有感染和无感染的儿童均表现出显著的季节变化（p<0.001），尽管两组之间的季节模式有所不同（p<0.001）。由于糖尿病发病率在25年期间有所增加，研究期被分为5年的时间段，仅在最后两个时间段出现了显著的季节变化。儿童1型糖尿病的诊断存在明显的季节变化，结果表明诊断时疾病进程较温和的儿童对此变化负有最大责任。有和无既往感染的儿童表现出不同的季节模式。
