Samuelsson Ulf, Stenhammar Lars
Department of Molecular and Clinical Medicine, Diabetes Research Centre and Division of Pediatrics, Linköping University, S-58185 Linköping, Sweden.
Diabetes Res Clin Pract. 2005 Apr;68(1):49-55. doi: 10.1016/j.diabres.2004.08.002.
To survey clinical characteristics at diagnosis for children diagnosed with Type 1 diabetes during 25 years in the south-east part of Sweden we included all 1903 children < 16 years of age and who had been diagnosed between 1977 and 2001 in the south-east region of Sweden. A nurse or doctor in the diabetes team obtained information from medical records. Over the 25 years the mean duration of symptoms prior to diagnosis was 17.8 +/- 26.4 days and the mean glucose level at diagnosis was 23.6 +/- 9.7 mmol/l. Three percent of the children (n = 50) had a pH value < or = 7.1. The youngest children (0-5 years) had shorter duration of symptoms, lower blood-glucose levels and less often had ketonuria than the oldest children (11-15 years) but more often suffered from infections prior to diagnosis. The proportion of children diagnosed in the group 0-5 years of age increased over the study-period, apart from the last 5 years, while children with pH value < or = 7.3 decreased significantly as did the proportion of children with ketonuria or infection. The clinical characteristics at diagnosis of diabetes are heterogeneous, especially in the oldest age group. Some characteristics varied with time.
为了调查瑞典东南部25年间确诊为1型糖尿病的儿童的诊断时临床特征，我们纳入了瑞典东南部地区所有1903名年龄小于16岁且在1977年至2001年期间被确诊的儿童。糖尿病团队的护士或医生从病历中获取信息。在这25年中，诊断前症状的平均持续时间为17.8 +/- 26.4天，诊断时的平均血糖水平为23.6 +/- 9.7 mmol/l。3%的儿童（n = 50）pH值≤7.1。最年幼的儿童（0 - 5岁）症状持续时间较短，血糖水平较低，与最大的儿童（11 - 15岁）相比，酮尿症较少见，但诊断前感染更常见。在研究期间，除了最后5年，0 - 5岁年龄组中确诊的儿童比例有所增加，而pH值≤7.3的儿童比例以及酮尿症或感染儿童的比例显著下降。糖尿病诊断时的临床特征具有异质性，尤其是在最大年龄组。一些特征随时间而变化。
