Khayyal M T, Seif-El-Nasr M, El-Ghazaly M A, Okpanyi S N, Kelber O, Weiser D
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt.
Phytomedicine. 2006;13 Suppl 5:56-66. doi: 10.1016/j.phymed.2006.03.019. Epub 2006 Sep 11.
The protective effect of a commercial preparation (STW 5, Iberogast), containing the extracts of bitter candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, liquorice root, Angelica root, milk thistle fruit and greater celandine herb, against the development of gastric ulcers was previously reported in an earlier publication (Khayyal et al., 2001). All extracts produced a dose dependent anti-ulcerogenic effect associated with a reduced acid output, an increased mucin secretion, an increase in prostaglandin E(2) release and a decrease in leukotrienes. The effect on pepsin content was not uniform and did not seem to bear a relationship with the anti-ulcerogenic activity. The best effects were observed with the combined formulation, STW 5. Furthermore, the effect of the latter in protecting against the development of rebound gastric acidity was examined experimentally in rats and compared with the effect of some commercial antacid preparations (Rennie, Talcid and Maaloxan). A model of testing rebound acidity was developed by inducing a marginal increase in gastric acidity through the administration of indomethacin, in such a way that it could be easily neutralized, allowing any eventual secondary increase in acidity to be measured within a few hours of administration. In addition, the serum gastrin level was measured after drug treatment to establish any correlation between it and any rebound acidity. The results obtained demonstrated that STW 5 did not only lower the gastric acidity as effectively as the commercial antacid, but it was more effective in inhibiting the secondary hyperacidity. Moreover, STW 5 was capable of inhibiting the serum gastrin level in rats, an effect which ran parallel to its lowering effect on gastric acid production.
一种商业制剂（STW 5，伊比罗格斯）含有苦糖果毛茛、柠檬香脂叶、洋甘菊花、葛缕子果实、薄荷叶、甘草根、当归根、水飞蓟果实和白屈菜全草的提取物，其对胃溃疡发展的保护作用先前已在一篇早期出版物中报道过（Khayyal等人，2001年）。所有提取物均产生剂量依赖性抗溃疡作用，伴有胃酸分泌减少、黏液分泌增加、前列腺素E(2)释放增加和白三烯减少。对胃蛋白酶含量的影响并不一致，似乎与抗溃疡活性无关。联合制剂STW 5观察到最佳效果。此外，在大鼠中通过实验研究了后者预防反弹性胃酸分泌增加的作用，并与一些市售抗酸制剂（雷尼替丁、铝碳酸镁和达喜）的作用进行了比较。通过给予吲哚美辛使胃酸略有增加来建立反弹性胃酸分泌的测试模型，这样可以很容易地将其中和，从而能够在给药后几小时内测量任何最终的继发性胃酸增加。此外，在药物治疗后测量血清胃泌素水平，以确定其与任何反弹性胃酸分泌增加之间的相关性。获得的结果表明，STW 5不仅能像市售抗酸剂一样有效地降低胃酸，而且在抑制继发性胃酸过多方面更有效。此外，STW 5能够抑制大鼠血清胃泌素水平，这一作用与其降低胃酸分泌的作用平行。
