Sai M, Kawanishi Y, Kuriyama K, Kuratsuji T, Toyama K
First Department of Internal Medicine, Tokyo Medical College.
Rinsho Ketsueki. 1990 Apr;31(4):484-6.
The cause of chronic idiopathic neutropenia (CIN) is unknown. Recently recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been purified. Many studies of effects of rhG-CSF on the patients with neutropenia have been undertaken. We examined changes in neutrophil counts and functions after the administration of rhG-CSF in a patient with CIN. Six hours after the intravenous administration of 40 micrograms of rhG-CSF, neutrophil counts were raised from 90 to 1570/microliters, and the increased neutrophils functioned normally; chemotaxis, phagocytosis and O2(-) generation. It is suggested that rhG-CSF is beneficial for the treatment of infection in patients with CIN.
慢性特发性中性粒细胞减少症（CIN）的病因尚不清楚。最近，重组人粒细胞集落刺激因子（rhG-CSF）已被纯化。已经对rhG-CSF对中性粒细胞减少症患者的影响进行了许多研究。我们检测了一名CIN患者在给予rhG-CSF后中性粒细胞计数和功能的变化。静脉注射40微克rhG-CSF 6小时后，中性粒细胞计数从90/微升升至1570/微升，且增加的中性粒细胞功能正常；趋化性、吞噬作用和O2（-）生成。提示rhG-CSF对CIN患者的感染治疗有益。
