Ashida T, Ishikawa H, Urase F, Satoh M, Tsubaki K, Horiuchi A
Rinsho Ketsueki. 1989 Oct;30(10):1778-82.
We studied the in vivo effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on white blood cell (WBC) count and neutrophil functions in nine patients with malignant lymphoma. The WBC count and absolute neutrophil count were rapidly increased without a nadir phase after chemotherapy. Neutrophil alkaline phosphatase (NAP) scores also markedly increased following chemotherapy in all patients. Phagocytosis of India ink and nitroblue tetrazolium (NBT) reduction were revealed tend to be increased, but not exceeded significantly to normal range. RhG-CSF repaired neutrophil function in patients with decreasing that. Thus, rhG-CSF may be useful for prevention and treatment of infection after chemotherapy.
我们研究了重组人粒细胞集落刺激因子（rhG-CSF）对9例恶性淋巴瘤患者白细胞（WBC）计数及中性粒细胞功能的体内作用。化疗后白细胞计数和绝对中性粒细胞计数迅速升高，无最低点期。所有患者化疗后中性粒细胞碱性磷酸酶（NAP）评分也显著升高。墨汁吞噬试验及硝基四氮唑蓝（NBT）还原试验显示有升高趋势，但未显著超过正常范围。rhG-CSF可修复功能降低患者的中性粒细胞功能。因此，rhG-CSF可能对化疗后感染的防治有用。
