Ticker Jonathan B, Flatow Evan L, Pawluk Robert J, Soslowsky Louis J, Ratcliffe Anthony, Arnoczky Steven P, Mow Van C, Bigliani Louis U
New York Orthopaedic Hospital Research Laboratory, Columbia-Presbyterian Medical Center, New York, NY, USA.
J Shoulder Elbow Surg. 2006 Nov-Dec;15(6):665-74. doi: 10.1016/j.jse.2005.11.006. Epub 2006 Sep 11.
The inferior glenohumeral ligament (IGHL) was investigated by correlating the biomechanical properties, biochemical composition, and histologic morphology of its 3 anatomic regions (superior band, anterior axillary pouch, and posterior axillary pouch) in 8 human cadaveric shoulders. The overall biochemical composition of the IGHL appeared similar to other ligaments, with average water content of 80.9 +/- 2.5%, collagen content of 80.0 +/- 9.2%, and crosslinks of 0.715 +/- 0.13 mol/mol collagen. The proteoglycan content was highest in the superior band (2.73 +/- 0.7 mg/g dry weight) and may, in part, explain its viscoelastic behavior. Histologic analysis demonstrated longitudinally organized fiber bundles that were more uniform in the mid-substance but more interwoven and less uniformly oriented near the insertion sites. The superior band had the most pronounced fiber bundle interweaving, while crimping was more evident in the anterior axillary pouch. Elastin was identified in each of the regions. Tensile testing demonstrated a trend toward higher ultimate tensile stress (16.9 +/- 7.9 MPa) and tensile modulus (130.3 +/- 47.9 MPa) in the superior band compared to the axillary pouch. The mean ultimate tensile strain of the IGHL was 16.8 +/- 4.6%. These complex IGHL properties may help to explain its unique functions in stabilizing the shoulder in different arm positions and at different rates of loading, including the failure patterns seen clinically, as in Bankart lesions (insertion site) versus capsular stretching (ligament substance).
通过对8例人类尸体肩部下盂肱韧带（IGHL）的3个解剖区域（上束、腋前襞和腋后襞）的生物力学特性、生化组成和组织形态进行相关性研究。IGHL的整体生化组成与其他韧带相似，平均含水量为80.9±2.5%，胶原蛋白含量为80.0±9.2%，交联度为0.715±0.13摩尔/摩尔胶原蛋白。蛋白聚糖含量在上束最高（2.73±0.7毫克/克干重），这可能部分解释了其粘弹性行为。组织学分析显示，纤维束呈纵向排列，在韧带中部更均匀，但在插入部位附近交织更多且排列方向更不一致。上束的纤维束交织最明显，而卷曲在腋前襞更明显。在每个区域都鉴定出了弹性蛋白。拉伸试验表明，与腋襞相比，上束的极限拉伸应力（16.9±7.9兆帕）和拉伸模量（130.3±47.9兆帕）有更高的趋势。IGHL的平均极限拉伸应变是16.8±4.6%。这些复杂的IGHL特性可能有助于解释其在稳定肩部于不同手臂位置和不同加载速率时的独特功能，包括临床上所见的失败模式，如Bankart损伤（插入部位）与关节囊拉伸（韧带实质）。
