胶原蛋白溶解度与皮肤光学清透性相关。

Collagen solubility correlates with skin optical clearing.

作者信息

Hirshburg Jason, Choi Bernard, Nelson J Stuart, Yeh Alvin T

出版信息

J Biomed Opt. 2006 Jul-Aug;11(4):040501. doi: 10.1117/1.2220527.

DOI:10.1117/1.2220527

Abstract

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

摘要

生物医学光学和光医学应用受到大多数生物组织系统浑浊度的挑战。非反应性、生物相容性化学试剂可诱导诸如人体皮肤等胶原组织的光学散射发生可逆性降低。在此我们表明，一种化学试剂的组织光学清除潜力与其胶原溶解性直接相关，这为有效的经皮制剂提供了合理的设计基础。