Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics - MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Wuhan, China.
Huazhong University of Science and Technology, School of Optical Electronic Information - Advanced Biomedical Imaging Facility, Wuhan, China.
J Biomed Opt. 2023 Jun;28(6):060901. doi: 10.1117/1.JBO.28.6.060901. Epub 2023 Jun 6.
Skin is the largest organ and also the first barrier of body. Skin diseases are common, and cutaneous microcirculation is relative to various diseases. Researchers attempt to develop novel imaging techniques to obtain the complex structure, components, and functions of skin. Modern optical techniques provide a powerful tool with non-invasiveness, but the imaging performance suffers from the turbid character of skin. skin optical clearing technique has been proposed to reduce tissue scattering and enhance penetration depth of light and became a hot topic of research.
The aim of this review is to provide a comprehensive overview of recent development of skin optical clearing methods, how skin optical clearing enhances imaging performance, and its applications in study and light therapy of various diseases.
Based on the references published over the last decade, the important milestones on the mechanism, methods, and its fundamental and clinical applications of skin optical clearing technique are provided.
With the deepening understanding of skin optical clearing mechanisms, efficient skin optical clearing methods were constantly screened out. These methods have been combined with various optical imaging techniques to improve imaging performances and acquire deeper and finer skin-related information. In addition, skin optical clearing technique has been widely applied in assisting study of diseases as well as achieving safe, high-efficiency light-induced therapy.
In the last decade, skin optical clearing technique has developed rapidly and played an important role in skin-related studies.
皮肤是人体最大的器官，也是第一道身体防线。皮肤疾病很常见，皮肤微循环与各种疾病有关。研究人员试图开发新的成像技术来获取皮肤的复杂结构、成分和功能。现代光学技术提供了一种强大的工具，具有非侵入性，但成像性能受到皮肤混浊的影响。皮肤光学透明技术被提出用于减少组织散射并增加光的穿透深度，成为研究的热门话题。
本综述旨在全面概述皮肤光学透明方法的最新发展，皮肤光学透明如何增强成像性能，以及其在各种疾病的研究和光疗中的应用。
基于过去十年发表的参考文献，提供了皮肤光学透明技术的机制、方法及其基础和临床应用的重要里程碑。
随着对皮肤光学透明机制的深入了解，不断筛选出有效的皮肤光学透明方法。这些方法已经与各种光学成像技术相结合，以提高成像性能并获取更深、更精细的皮肤相关信息。此外，皮肤光学透明技术已广泛应用于辅助疾病研究以及实现安全、高效的光诱导治疗。
在过去的十年中，皮肤光学透明技术发展迅速，在皮肤相关研究中发挥了重要作用。
