Green Michael F
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, and the VA Greater Los Angeles Healthcare System 90095-6968, USA.
J Clin Psychiatry. 2006;67 Suppl 9:3-8; discussion 36-42.
A considerable amount of evidence supports the relationship between cognitive impairment and functional outcomes in schizophrenia. Cognitive impairment is considered a core feature of schizophrenia that includes problems in speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. These deficits can also serve as an endophenotype for the illness in studies of genetics. Cognition is considered a reasonable treatment target in individuals with schizophrenia, partly because cognitive deficits contribute to poor functional outcomes. Similarly, evidence is beginning to emerge that cognitive impairment may also be a core feature of bipolar disorder. In addition, cognitive deficits adversely affect functional outcomes in bipolar disorder. This evidence suggests that cognition can be considered a reasonable target for intervention in both schizophrenia and bipolar disorder.
大量证据支持精神分裂症中认知障碍与功能结局之间的关系。认知障碍被认为是精神分裂症的核心特征，包括处理速度、注意力/警觉性、工作记忆、言语学习、视觉学习、推理和问题解决以及社会认知方面的问题。在遗传学研究中，这些缺陷也可作为该疾病的内表型。认知被认为是精神分裂症患者合理的治疗靶点，部分原因是认知缺陷会导致不良的功能结局。同样，有证据开始表明认知障碍也可能是双相情感障碍的核心特征。此外，认知缺陷对双相情感障碍的功能结局有不利影响。这一证据表明，认知可被视为精神分裂症和双相情感障碍干预的合理靶点。
