真性红细胞增多症患者红细胞中的戊糖分流、磷酸核糖焦磷酸生成及嘌呤磷酸核糖转移酶
Pentose shunt, phosphoribosylpyrophosphate generation and purine-phosphoribosyltransferases in erythrocytes of patients with polycythemia vera.
作者信息
Sperling O, Boer P, Brosh S, Elazar E, Pinkhas J, Szeinberg A, de Vries A
出版信息
Acta Haematol. 1975;54(2):75-81. doi: 10.1159/000208055.
PMID:169659
Abstract
Erythrocytes of patients with polycythemia vera exhibited increased activity of oxidative pentose shunt, accelerated generation of phosphoribosylpyrophosphate, increased incorporation of 14C-adenine into nucleotides, and increased activity and thermostability of adenine-phosphoribosyltransferase. These abnormalities are attributed to age dependency of the pathways concerned and presence in polycythemia vera of an erythrocyte population younger than normal.
摘要
真性红细胞增多症患者的红细胞表现出氧化戊糖旁路活性增加、磷酸核糖焦磷酸生成加速、14C-腺嘌呤掺入核苷酸增加以及腺嘌呤磷酸核糖转移酶活性和热稳定性增加。这些异常归因于相关途径的年龄依赖性以及真性红细胞增多症中存在比正常情况更年轻的红细胞群体。
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