[某些贫血类型红细胞中的磷酸核糖焦磷酸及其代谢酶]

[Phosphoribosyl pyrophosphate and its metabolic enzymes in the erythrocytes in certain forms of anemia].

作者信息

Blinov M N, Kamyshentsev M V, Luganova I S, Filanovskaia L I, Filippova V N

出版信息

Vopr Med Khim. 1976 Jul-Aug;22(4):456-62.

Abstract

Content of phosphoribosyl pyrophosphate and the activity of ribose phosphate pyrophosphokinase and AMP-pyrophosphorylase were studied in erythrocytes of healthy persons and of patients with various types of anemia. Deficiency of phosphoribosyl pyrophosphate and a decrease in the activity of enzymes studied were observed in erythrocytes under microspherocytic and hypoplastic anemia. The alterations correlated with impairments in energy metabolism. At the same time an activation of phosphoribosyl pyrophosphate enzymatic system and an increase of its content in erythrocytes did not depend on energy metabolism in Marchiafava--Micheli disease.

摘要

对健康人和各类贫血患者红细胞中的磷酸核糖焦磷酸含量以及磷酸核糖焦磷酸激酶和AMP-焦磷酸化酶的活性进行了研究。在小球形红细胞性贫血和再生障碍性贫血患者的红细胞中，观察到磷酸核糖焦磷酸缺乏以及所研究酶的活性降低。这些改变与能量代谢受损相关。同时，在Marchiafava - Micheli病中，磷酸核糖焦磷酸酶系统的激活及其在红细胞中的含量增加并不依赖于能量代谢。

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[Phosphoribosyl pyrophosphate and its metabolic enzymes in the erythrocytes in certain forms of anemia].[某些贫血类型红细胞中的磷酸核糖焦磷酸及其代谢酶]

Vopr Med Khim. 1976 Jul-Aug;22(4):456-62.

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HGPRT deficiency with normal erythrocyte PRPP and APRT activity.伴有正常红细胞磷酸核糖焦磷酸（PRPP）和腺嘌呤磷酸核糖转移酶（APRT）活性的次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）缺乏症。

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Normal activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate in erythrocytes of patients with primary metabolic gout.原发性代谢性痛风患者红细胞中参与磷酸核糖焦磷酸形成和利用的代谢途径的正常活性。

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