Sprenger A, Rambold H, Sander T, Marti S, Weber K, Straumann D, Helmchen C
Department of Neurology, University of Lübeck, Germany.
Neurology. 2006 Sep 12;67(5):905-7. doi: 10.1212/01.wnl.0000233829.76150.6b.
The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45 degrees ), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.
作者研究了3,4-二氨基吡啶（DAP）对11例特发性小脑共济失调患者下跳性眼球震颤重力依赖性（GD）垂直眼漂移成分的影响。当头向下倾斜45度时，DAP使11例患者中的7例慢相速度（SPV）降低了36%。其疗效与GD调节相关。DAP可将重力非依赖性速度偏差降至最低，并可能改善小脑对过度活跃的耳石-眼反射的抑制控制不足。
