Lim Choon Hak, Son Ho Sung, Fang Yung Hu, Lee Jung Joo, Baik Kwang Je, Kim Kyung Hyun, Kim Bum Soo, Lee Hye Won, Sun Kyung
Anesthesiology and Pain Medicine, Korea University, Seoul, Korea.
ASAIO J. 2006 Sep-Oct;52(5):592-4. doi: 10.1097/01.mat.0000237692.12805.01.
We examined the pulsatility generated by an intra-aortic balloon pump/centrifugal pump (IABP/CP) combination in terms of energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE). In five cardiac-arrested pigs, the outflow cannula of the CP was inserted into the ascending aorta, the inflow cannula in the right atrium. A 30-ml IABP was subsequently placed in the descending aorta. Extracorporeal circulation was maintained for 30 minutes using a pump flow of 75 ml/kg per minute by CP alone or by IABP/CP with pressure and flow measured in the right internal carotid artery. The IABP/CP combination converted the flow to pulsatile and increased pulse pressure significantly from 9.1 +/- 1.3 mm Hg to 54.9 +/- 6.1 mm Hg (p = 0.012). It also significantly increased the percent change from mean arterial pressure to EEP from 0.2 +/- 0.3% to 23.3 +/- 6.1% (p = 0.012) and SHE from 133.2 +/- 234.5 erg/cm to 20,219.8 +/- 5842.7 erg/cm3 (p = 0.012). However, no statistical difference was observed between CP and IABP/CP in terms of mean carotid artery pressure (p = NS). In a cardiac-arrested animal model, pulsatility generated by a IABP/CP combination may be effective in terms of energy equivalent pressure and surplus hemodynamic energy.
我们从能量等效压力（EEP）和剩余血流动力学能量（SHE）方面研究了主动脉内球囊泵/离心泵（IABP/CP）组合产生的搏动性。在五只心脏骤停的猪中，将CP的流出插管插入升主动脉，流入插管插入右心房。随后在降主动脉中放置一个30毫升的IABP。单独使用CP或使用IABP/CP以每分钟75毫升/千克的泵流量维持体外循环30分钟，并测量右颈内动脉的压力和流量。IABP/CP组合使血流转变为搏动性，并使脉压从9.1±1.3毫米汞柱显著增加至54.9±6.1毫米汞柱（p = 0.012）。它还使平均动脉压到EEP的百分比变化从0.2±0.3%显著增加至23.3±6.1%（p = 0.012），以及SHE从133.2±234.5尔格/立方厘米增加至20219.8±5842.7尔格/立方厘米（p = 0.012）。然而，在平均颈动脉压方面，CP和IABP/CP之间未观察到统计学差异（p =无显著性差异）。在心脏骤停动物模型中，IABP/CP组合产生的搏动性在能量等效压力和剩余血流动力学能量方面可能是有效的。
