Kalcheim Chaya, Kahane Nitza, Cinnamon Yuval, Ben-Yair Raz
Department of Anatomy and Cell Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Anat Embryol (Berl). 2006 Dec;211 Suppl 1:31-6. doi: 10.1007/s00429-006-0116-y. Epub 2006 Sep 12.
The somite and its intermediate derivatives, sclerotome and dermomyotome (DM), are composed of distinct subdomains based on lineage analysis and gene expression patterns. This sets the grounds for elucidating the mechanisms underlying differential cell specification and morphogenesis. By examining the in vivo roles of N-cadherin on discrete domains of the somitic epithelium at various times, our recent studies highlight the existence of a regional and temporal heterogeneity in cellular responsiveness. As examples of this assortment, we document a coupling between asymmetric cell division and fate segregation in the DM sheet, sequential effects of N-cadherin-mediated adhesion on early myogenic specification compared to later myofiber patterning, and a differential behavior of pioneer myoblasts compared to later myogenic waves.
体节及其中间衍生物，即生骨节和皮肌节（DM），根据谱系分析和基因表达模式由不同的亚结构域组成。这为阐明细胞特异性分化和形态发生的潜在机制奠定了基础。通过在不同时间检查N-钙黏蛋白在体节上皮离散区域的体内作用，我们最近的研究突出了细胞反应性存在区域和时间异质性。作为这种多样性的例子，我们记录了DM层中不对称细胞分裂与命运分离之间的耦合、与后期肌纤维模式相比N-钙黏蛋白介导的黏附对早期肌源性分化的顺序影响，以及先驱成肌细胞与后期肌源性波相比的不同行为。
