Deries Marianne, Thorsteinsdóttir Sólveig
Centro de Ecologia, Evolução e Alterações Ambientais, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.
Cell Mol Life Sci. 2016 Dec;73(23):4415-4431. doi: 10.1007/s00018-016-2298-7. Epub 2016 Jun 25.
Skeletal muscles are part of the musculoskeletal system which also includes nerves, tendons, connective tissue, bones and blood vessels. Here we review the development of axial and limb muscles in amniotes within the context of their surrounding tissues in vivo. We highlight the reciprocal dialogue mediated by signalling factors between cells of these adjacent tissues and developing muscles and also demonstrate its importance from the onset of muscle cell differentiation well into foetal development. Early embryonic tissues secrete factors which are important regulators of myogenesis. However, later muscle development relies on other tissue collaborators, such as developing nerves and connective tissue, which are in turn influenced by the developing muscles themselves. We conclude that skeletal muscle development in vivo is a compelling example of the importance of reciprocal interactions between developing tissues for the complete and coordinated development of a functional system.
骨骼肌是肌肉骨骼系统的一部分，该系统还包括神经、肌腱、结缔组织、骨骼和血管。在此，我们在体内周围组织的背景下，综述羊膜动物轴肌和肢体肌肉的发育。我们强调这些相邻组织的细胞与发育中的肌肉之间由信号因子介导的相互对话，并证明其从肌肉细胞分化开始直至胎儿发育阶段的重要性。早期胚胎组织分泌的因子是肌生成的重要调节因子。然而，后期肌肉发育依赖于其他组织协作伙伴，如发育中的神经和结缔组织，而这些组织又反过来受发育中的肌肉自身影响。我们得出结论，体内骨骼肌发育有力地证明了发育中的组织之间相互作用对于功能系统完整且协调发育的重要性。
