Tohnai Iwai
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Japan.
Nagoya J Med Sci. 2006 Jun;68(3-4):101-8.
There are three historically recognized methods of intra-arterial infusion for oral cancer: Conventional intra-arterial infusion via the superficial temporal artery: Superselective intra-arterial infusion via the femoral artery (Seldinger method), New superselective intra-arterial infusion via the superficial temporal artery. Here we report a recent instance of daily concurrent chemoradiotherapy using a new superselective intra-arterial infusion. A catheter with a curved tip was inserted superselectively into the feeding artery of the tumor via the superficial temporal artery (long-term catheterization has become possible using this method). The patient with T3 tongue cancer was treated by chemoradiotherapy. Radiotherapy (total dose: 40 Gy/4weeks) and superselective intra-arterial infusion chemotherapy using docetaxel (DOC) (total dose: 60 mg/m2/4weeks, 15 mg/m2/week) and cisplatin (CDDP) (total dose: 100 mg/m2/4weeks, 5 mg/m2/day) were concurrently performed daily, followed by surgery, after which no major complication was observed. The clinical effect was complete response (CR), and the pathological effect on the resected tumor after surgery was pathological CR. This method promises to be a new strategy of choice for the treatment of oral cancer.
经颞浅动脉的传统动脉内灌注；经股动脉的超选择性动脉内灌注（塞丁格法）；经颞浅动脉的新型超选择性动脉内灌注。在此，我们报告一例近期使用新型超选择性动脉内灌注进行每日同步放化疗的病例。通过颞浅动脉将尖端弯曲的导管超选择性插入肿瘤的供血动脉（使用该方法已可实现长期置管）。对一名T3期舌癌患者进行了放化疗。每日同步进行放疗（总剂量：40 Gy/4周）以及使用多西他赛（DOC）（总剂量：60 mg/m²/4周，15 mg/m²/周）和顺铂（CDDP）（总剂量：100 mg/m²/4周，5 mg/m²/天）的超选择性动脉内灌注化疗，随后进行手术，术后未观察到重大并发症。临床疗效为完全缓解（CR），术后切除肿瘤的病理疗效为病理完全缓解。该方法有望成为治疗口腔癌的一种新的首选策略。
