Tohnai I, Fuwa N, Hayashi Y, Kaneko R, Tomaru Y, Hibino Y, Ueda M
Department of Oral Surgery, Nagoya University School of Medicine, Japan.
Oral Oncol. 1998 Sep;34(5):387-90. doi: 10.1016/s1368-8375(98)00018-9.
We developed a new technique of superselective intra-arterial chemotherapy for tongue cancer using a modified (1.35 mm) angiographic catheter. The catheter was confirmed to be inserted into the lingual artery by the new technique. We measured the platinum concentrations in resected tumour tissues after infusion of carboplatin (CBDCA) at 20 mg/m2 over 30 min from 30 min before tumour resection in 12 patients with cancer of the tongue (6 patients: superselective intra-arterial infusion; 6 patients: conventional intra-arterial infusion). The mean platinum concentration in tumour tissue was 10.5 +/- 1.2 micrograms/g wet, which was more than twice higher than, and significantly different from, 4.3 +/- 3.8 micrograms/g wet by the conventional intra-arterial infusion method. This new superselective intra-arterial infusion method allows direct infusion of the anticancer agent into the artery supplying the tumour and is expected to become a new therapeutic modality for cancer of the tongue.
我们使用改良的（1.35毫米）血管造影导管开发了一种用于舌癌的超选择性动脉内化疗新技术。通过新技术确认导管已插入舌动脉。我们在12例舌癌患者（6例：超选择性动脉内灌注；6例：传统动脉内灌注）肿瘤切除前30分钟开始，在30分钟内以20mg/m²的剂量输注卡铂（CBDCA）后，测量切除肿瘤组织中的铂浓度。肿瘤组织中的平均铂浓度为10.5±1.2微克/克湿重，比传统动脉内灌注法的4.3±3.8微克/克湿重高出两倍多，且有显著差异。这种新的超选择性动脉内灌注方法允许将抗癌剂直接注入供应肿瘤的动脉，有望成为舌癌的一种新治疗方式。
