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[Chemosynthetic peptides against foot-and-mouth disease--immune response to free and carrier bound peptides of the VP1 of O1-Kaufbeuren].

作者信息

Liebermann H, Reimann I, Bartels T, Nöckler A, Thalmann G, Furkert J, Dölling R

机构信息

VEB Friedrich-Loeffler-Institut Insel Riems, Betrieb des VEB Kombinat Veterinärimpfstoffe Dessau, DDR Berlin.

出版信息

Arch Exp Veterinarmed. 1990;44(2):189-97.

PMID:1696803
Abstract

Three peptides of main epitope of FMD virus O1-Kaufbeuren, VP1 (16, 21, 31), were found to induce in the 130-160 sequence range, in free and/or carrier-bonded form, virus-neutralising antibodies in guinea pig, rabbit, mouse, swine, and cattle. Five carrier proteins were tested, with thyroglobulin, next to keyhole limpet hemocyanin (KLH), being most effective for 16-peptides (145-160) and 21-peptides (141-160 Tyr161). To protect guinea pig from FMD, minimum dosage of 21-peptide was found to be 2 x 8 micrograms. The immunogenic spectrum of peptides and conjugates proved to be broader than that of monovalent vaccines of inactivated virus. Free peptides were found to be also capable in vitro of inhibiting virus infection.

摘要

相似文献

1
[Chemosynthetic peptides against foot-and-mouth disease--immune response to free and carrier bound peptides of the VP1 of O1-Kaufbeuren].
Arch Exp Veterinarmed. 1990;44(2):189-97.
2
Synthetic peptides against foot-and-mouth disease--immunization with VP1-peptides of type O1-Kaufbeuren.抗口蹄疫合成肽——用O1-考夫博伊伦型VP1肽进行免疫接种
Arch Exp Veterinarmed. 1990;44(6):883-90.
3
Investigation of the influence of peptide-carrier conjugation on the immunological activity of VP1-peptides of foot-and-mouth disease virus O1-Kaufbeuren.肽-载体偶联对口蹄疫病毒O1-考夫博伊伦株VP1肽免疫活性的影响研究
Arch Exp Veterinarmed. 1990;44(6):873-81.
4
[Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22].[口蹄疫病毒的抗原结构。II. A22型口蹄疫病毒VP1蛋白主要免疫原区保护性肽的合成]
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5
Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.使用绵羊多克隆抗体和单克隆抗体分析绵羊对口蹄疫病毒合成肽的免疫反应。
Immunology. 1990 Jan;69(1):1-7.
6
[Synthetic peptides simulating the protective epitopes of VP1 protein of foot-and-mouth disease virus type O and A].[模拟O型和A型口蹄疫病毒VP1蛋白保护性表位的合成肽]
Bioorg Khim. 1987 Aug;13(8):1132-5.
7
Protection against viral infections with the aid of synthetic peptides. Foot-and-mouth disease as an example.借助合成肽预防病毒感染。以口蹄疫为例。
Biomed Sci. 1990 Jan;1(1):23-32.
8
[Antigenic structure of foot-and-mouth virus. IV. Synthesis and immunogenic properties of new fragments of the VP1 protein of food-and-mouth virus strain A22].
Bioorg Khim. 1989 Sep;15(9):1193-205.
9
[Antigenic structure of the foot-and-mouth disease virus. III. Immunogenic properties of synthetic peptides of the sequence of the immunodominant region of VP1 proteins of the O1K and A22 strains of foot-and-mouth virus].[口蹄疫病毒的抗原结构。III. 口蹄疫病毒O1K和A22株VP1蛋白免疫显性区序列合成肽的免疫原性]
Bioorg Khim. 1989 Sep;15(9):1185-92.
10
[Antigenic structure of the foot-and-mouth-disease virus. I. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth virus type O1K].[口蹄疫病毒的抗原结构。I. 从O1K型口蹄疫病毒VP1蛋白主要免疫原性区域合成保护性肽段]
Bioorg Khim. 1988 Oct;14(10):1352-62.

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