Francis D P, Herrmann K L, MacMahon J R, Chavigny K H, Sanderlin K C
Am J Dis Child. 1975 Aug;129(8):889-93. doi: 10.1001/archpedi.1975.02120450005003.
Four fatal cases of neonatal herpes simplex infection occurred during a two-month period in the perinatal intensive care unit of a hospital. Virus isolation or serologic studies, or both, implicated herpesvirus hominis type 2 in all four cases. Three of the infants developed symptoms in the first week of life and were probably infected in utero or at delivery. The fourth infant did not develop signs of illness until age 6 weeks, an interval much longer than that expected with disease acquired at birth. An epidemiologic investigation indicated that the most likely source of this fourth infant's herpes infection was by indirect contact with one of the other three infected neonates. Nosocomial spread of herpes simplex virus within a hospital nursery, although uncommon, may pose an added risk to the newborn infant if nursery techniques among infants are compromised.
在一家医院的围产期重症监护病房，两个月内发生了4例新生儿单纯疱疹感染致死病例。病毒分离或血清学研究，或两者兼用，在所有4例病例中均表明为2型人疱疹病毒。其中3例婴儿在出生后第一周出现症状，可能是在子宫内或分娩时感染。第4例婴儿直到6周龄才出现疾病体征，这一间隔时间比出生时获得的疾病预期长得多。一项流行病学调查表明，第4例婴儿疱疹感染最可能的来源是与其他3例受感染新生儿之一间接接触。单纯疱疹病毒在医院托儿所内的医院感染传播虽然不常见，但如果婴儿护理技术存在缺陷，可能会给新生儿带来额外风险。
