Ohsako Tomofumi, Inoue Katsuhiko, Nagamoto Norihide, Yoshida Yasushi, Nakahara Osamu
Dept. of Surgery, Labour Health and Welfare Organization, Kumamoto Rosai Hospital.
Gan To Kagaku Ryoho. 2006 Sep;33(9):1301-3.
We report two cases of recurrent breast cancer with regional lymph node metastases that responded completely to treatment with trastuzumab and paclitaxel. Case 1: A 52-year-old woman, who presented with left breast cancer, underwent mastectomy and axillary lymph node dissection in July 2002. Pathological findings were as follows: invasive ductal carcinoma (scirrhous type), 2.2 cm in size, histological grade 3, positive invasion to the lymphatic and blood vessels, negative nodal status (0/11), negative ER/PgR status, and overexpression of HER 2/neu. Left axillary lymph node metastasis was noted after five months, ie, in December 2002. Four cycles of chemotherapy with doxorubicin and cyclophosphamide were administered from January 2003; however, they were not effective. The patient showed a complete response after three months of chemotherapy with trastuzumab and paclitaxel. This treatment was stopped in September 2003. She has maintained a complete response for two and a half years and was not administered any further treatment as of February 2006. Case 2: A 59-year-old woman, who presented with right breast cancer, underwent mastectomy and axillary lymph node dissection in May 2002. Pathological findings were as follows: invasive ductal carcinoma (scirrhous type), 1.8 cm in size, histological grade 2, positive invasion to the lymphatic and blood vessels, negative nodal status (0/5), positive ER and uncertain PgR status, and overexpression of HER 2/neu. She had received adjuvant hormonal therapy with tamoxifen; however, a right supraclavicular lymph node metastasis was noted in October 2004. Treatment with exemestane was not effective. However, a complete response was observed with trastuzumab and paclitaxel for four months. She has maintained a complete response for six months and was not administered any further treatment as of February 2006.
我们报告了两例复发性乳腺癌伴区域淋巴结转移的病例，这两例患者接受曲妥珠单抗和紫杉醇治疗后完全缓解。病例1：一名52岁女性，因左乳腺癌就诊，于2002年7月接受了乳房切除术和腋窝淋巴结清扫术。病理结果如下：浸润性导管癌（硬癌型），大小为2.2厘米，组织学分级为3级，淋巴管和血管侵犯阳性，淋巴结阴性（0/11），雌激素受体/孕激素受体状态阴性，HER 2/neu过表达。2002年12月，即五个月后发现左腋窝淋巴结转移。从2003年1月开始给予四个周期的阿霉素和环磷酰胺化疗；然而，这些治疗无效。患者在接受曲妥珠单抗和紫杉醇化疗三个月后出现完全缓解。该治疗于2003年9月停止。她已维持完全缓解两年半，截至2006年2月未接受任何进一步治疗。病例2：一名59岁女性，因右乳腺癌就诊，于2002年5月接受了乳房切除术和腋窝淋巴结清扫术。病理结果如下：浸润性导管癌（硬癌型），大小为1.8厘米，组织学分级为2级，淋巴管和血管侵犯阳性，淋巴结阴性（0/5），雌激素受体阳性，孕激素受体状态不确定，HER 2/neu过表达。她接受了他莫昔芬辅助激素治疗；然而，2004年10月发现右锁骨上淋巴结转移。依西美坦治疗无效。然而，使用曲妥珠单抗和紫杉醇治疗四个月后观察到完全缓解。她已维持完全缓解六个月，截至2006年2月未接受任何进一步治疗。
