Toshimitsu Hiroaki, Matoba Katsuhiro, Ozasa Hiroaki, Shimizu Ryoichi
Dept. of Surgery, Ogori Daiichi General Hospital.
Gan To Kagaku Ryoho. 2006 Sep;33(9):1329-32.
We encountered a resected case of advanced gastric cancer after successful chemotherapy. The patient remained alive in good condition without any signs of recurrence at 2 years and 8 months after surgery. The 40-year-old woman initially complained of low abdominal pain, which was diagnosed as gastric cancer with metastasis of ovaries and carcinomatous ascites. We administered TS-1 (100 mg/body/day) for 3 weeks followed by 2-week rest and CDDP (60 mg/body) on the 8th day of one cycle. After 3 cycles of treatment, carcinomatous ascites disappeared and the ovarian lesion was reduced. The patient underwent total gastrectomy, ileocecal resection, cholecystectomy and radical hysterectomy. The antitumor efficacy of the treatment was histologically Grade 2. We administered 17 cycles of TS-1 treatment, and the patient is alive in good condition at this writing. This shows that TS-1 and CDDP may have potent therapeutic efficacy in advanced gastric cancer patients. For the future, the safety and efficacious administration of TS-1 and CDDP should be examined further.
我们遇到了一例晚期胃癌患者，在成功进行化疗后接受了手术切除。患者术后2年8个月仍存活，状况良好，无任何复发迹象。这位40岁的女性最初抱怨下腹部疼痛，被诊断为胃癌伴卵巢转移和癌性腹水。我们给予替吉奥（TS-1，100毫克/体/天）治疗3周，随后休息2周，并在一个周期的第8天给予顺铂（CDDP，60毫克/体）。经过3个周期的治疗，癌性腹水消失，卵巢病变缩小。患者接受了全胃切除术、回盲部切除术、胆囊切除术和根治性子宫切除术。治疗的抗肿瘤疗效在组织学上为2级。我们给予了17个周期的替吉奥治疗，撰写本文时患者状况良好，仍存活。这表明替吉奥和顺铂在晚期胃癌患者中可能具有强大的治疗效果。未来，应进一步研究替吉奥和顺铂的安全性和有效给药方式。
