Hiraoka Kazuya, Mizutani Shin, Oyama Tsukasa, Uchikoshi Fumihiro, Yoshidome Katsuhide, Tori Masayuki, Ueshima Shigeyuki, Yamagami Yuko, Takahashi Hidekazu, Nakahara Masaaki, Tsujimoto Masahiko
Dept. of Surgery, Osaka Police Hospital.
Gan To Kagaku Ryoho. 2007 Jan;34(1):93-5.
A 72-year-old male with advanced gastric cancer (cT3N2M0H0P0CY1, cStage IV) was treated with TS-1/CDDP as neoadjuvant chemotherapy. TS-1 (60 mg/m(2)/day) was orally administered for 3 weeks followed by 2 drug free weeks as a course, and CDDP (60 mg/m(2)) was administered by intravenous drip on day 8. After the fourth course,a significant tumor reduction was obtained. Total gastrectomy, splenectomy, and D 2 type nodal dissection were performed. The histological diagnosis revealed complete disappearance of cancer cells in the stomach and all of the lymph nodes, which is a so-called pathological complete response. The patient has now been in good health without a recurrence for 24 months after surgery. This case suggests that neoadjuvant chemotherapy with TS-1/CDDP is a potential regimen for advanced gastric cancer.
一名72岁晚期胃癌男性患者（cT3N2M0H0P0CY1，c期IV）接受替吉奥/顺铂新辅助化疗。替吉奥（60mg/m²/天）口服3周，随后停药2周为一个疗程，顺铂（60mg/m²）于第8天静脉滴注。四个疗程后，肿瘤显著缩小。行全胃切除术、脾切除术及D2型淋巴结清扫术。组织学诊断显示胃及所有淋巴结癌细胞完全消失，即所谓的病理完全缓解。该患者术后24个月身体健康，无复发。本病例提示替吉奥/顺铂新辅助化疗是晚期胃癌的一种潜在治疗方案。
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