Pérez Molina J Jesús, Blancas Jacobo Olivia, Ramírez Valdivia Juan Manuel
División de Pediatría Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Jalisco, México.
Ginecol Obstet Mex. 2006 Jul;74(7):354-9.
To identify maternal and neonatal risk factors associated with hyaline membrane disease and its mortality.
A case-control study with 41 newborns with hyaline membrane disease and 123 controls was made between September 2001 and February 2002 in the Hospital Civil de Guadalajara Dr. Juan I. Menchaca. The diagnosis of hyaline membrane disease was done with clinical and radiographic data. Maternal risk factors were obtained by direct interview with the mother; the newborn data were obtained of the clinical files. The association was measured with the odds ratios (OR) and the confidence interval of 95%.
The frequency of hyaline membrane disease was of 6.8 per 1,000 live births. Mortality rate was of 2.8 per 1,000 live births. There were 17 deaths (41%). The risk factors associated with hyaline membrane were: illness during the first and second trimester of pregnancy, (OR: 3.28 [1.16-9.31]; OR: 8.88 [3.56-22.50], respectively), Apgar score lower than seven at the first minute (OR: 18.57 [4.50-88.67]), and masculine gender (OR: 2.58 [1.15-5.83]).
Frequency and mortality were similar to the reported by other studies made in population samples. The exposure to illnesses during pregnancy and the low Apgar score were associated with the increased frequency of hyaline membrane disease.
确定与透明膜病及其死亡率相关的孕产妇和新生儿危险因素。
2001年9月至2002年2月在瓜达拉哈拉市胡安·I·门查卡公民医院对41例患有透明膜病的新生儿和123例对照进行了病例对照研究。根据临床和影像学数据对透明膜病进行诊断。通过直接与母亲访谈获取孕产妇危险因素；从临床病历中获取新生儿数据。采用比值比（OR）和95%置信区间来衡量关联性。
透明膜病的发生率为每1000例活产中有6.8例。死亡率为每1000例活产中有2.8例。有17例死亡（41%）。与透明膜病相关的危险因素包括：妊娠前三个月和第二个月患病（OR分别为：3.28[1.16 - 9.31]；8.88[3.56 - 22.50]）、出生后第一分钟阿氏评分低于7分（OR：18.57[4.50 - 88.67]）以及男性性别（OR：2.58[1.15 - 5.83]）。
发生率和死亡率与其他针对人群样本的研究报告相似。孕期患病和低阿氏评分与透明膜病发生率增加相关。
