Lewis D L, Lechleiter J D, Kim D, Nanavati C, Clapham D E
Department of Pharmacology, Mayo Clinic, Rochester, MN 55905.
Mayo Clin Proc. 1990 Aug;65(8):1127-43. doi: 10.1016/s0025-6196(12)62726-8.
Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.
细胞通过细胞膜上的受体蛋白与周围环境进行通信。一些离子通道是受体，而其他离子通道则通过鸟嘌呤核苷酸结合蛋白（G蛋白）与受体相连。离子通道控制细胞内诸如钙等离子的浓度，而这些浓度则控制诸如分泌和细胞分裂等细胞功能。本综述总结了关于离子通道调控的当前知识状态。
