Swaner J C, Connor W E
Am J Physiol. 1975 Aug;229(2):365-9. doi: 10.1152/ajplegacy.1975.229.2.365.
After the establishment of a relatively linear decay curve for plasma [4-14C]cholesterol, rabbits were starved for 26-32 days. The plasma cholesterol concentration increased 400% during starvation. Concurrently, the plasma triglyceride level declined by 50%. While the plasma cholesterol was rising, the cholesterol specific radioactivity of the plasma remained unchanged in starved animals, but in control animals the plasma cholesterol specific radioactivity declined substantially. The cholesterol content of the liver and adipose tissue increased with starvation. The cholesterol specific radioactivities relative to plasma for adipose tissue were lower in the starved animals versus controls. These results support the hypothesis that cholesterol stored in the lipid droplet of the adipose tissue cell is released into plasma and is the chief source of the hypercholesterolemia observed during complete caloric starvation. Cholesterol metabolism in the starved animal can be depicted as a virtually closed system in both the input from biosynthesis and diet being low or zero and the output likewise being close to zero.
在建立了血浆[4-14C]胆固醇相对线性的衰变曲线后，兔子被禁食26 - 32天。禁食期间血浆胆固醇浓度增加了400%。同时，血浆甘油三酯水平下降了50%。在血浆胆固醇上升时，饥饿动物血浆中胆固醇的比放射性保持不变，但对照动物血浆胆固醇比放射性大幅下降。肝脏和脂肪组织中的胆固醇含量随饥饿增加。与对照相比，饥饿动物脂肪组织相对于血浆的胆固醇比放射性较低。这些结果支持了这样的假说，即储存在脂肪组织细胞脂滴中的胆固醇释放到血浆中，是完全热量饥饿期间观察到的高胆固醇血症的主要来源。饥饿动物的胆固醇代谢可以描述为一个几乎封闭的系统，生物合成和饮食的输入低或为零，输出同样接近零。
