Hollingworth Paul, Hamshere Marian L, Moskvina Valentina, Dowzell Kimberley, Moore Pamela J, Foy Catherine, Archer Nicola, Lynch Aoibhinn, Lovestone Simon, Brayne Carol, Rubinsztein David C, Lawlor Brian, Gill Mike, Owen Michael J, Williams Julie
Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom.
J Am Geriatr Soc. 2006 Sep;54(9):1348-54. doi: 10.1111/j.1532-5415.2006.00854.x.
To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment.
Cross-sectional study.
Data were collected from community-dwelling individuals and those residing in nursing homes.
A total of 1,120 individuals meeting National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria for late-onset probable AD.
Behavioral symptoms were assessed using the Neuropsychiatric Inventory. First-order polychoric correlations, controlling for disease severity, between the 12 symptom domain scores were estimated, and the resulting matrix underwent principal components analysis.
Four interpretable components were identified: behavioral dyscontrol (euphoria, disinhibition, aberrant motor behavior, and sleep and appetite disturbances), psychosis (delusions and hallucinations), mood (depression, anxiety, and apathy), and agitation (aggression and irritability). Scores on the four components were associated with severity of cognitive impairment. Higher behavioral dysfunction, agitation, and mood component scores were associated with lower age at onset. Behavioral dysfunction and mood component scores were associated with sex. None of the components were associated with age at assessment, years of education, or number of APOE epsilon4 alleles.
Four behavioral components were identified that were comparable with those observed previously. Future analysis of these components will strengthen understanding of the underlying pathology of behavioral symptoms and AD.
研究阿尔茨海默病（AD）的行为成分，并分析行为成分与疾病严重程度、载脂蛋白E基因型（APOE）、性别、受教育年限、发病年龄及认知障碍之间的关系。
横断面研究。
数据收集自社区居住个体及养老院居住者。
共1120名符合美国国立神经疾病与中风研究所/阿尔茨海默病及相关疾病协会晚发型可能AD标准的个体。
使用神经精神科问卷评估行为症状。估计12个症状领域得分之间的一阶多系列相关系数（控制疾病严重程度），并对所得矩阵进行主成分分析。
识别出四个可解释的成分：行为失控（欣快、脱抑制、异常运动行为以及睡眠和食欲障碍）、精神病性症状（妄想和幻觉）、情绪（抑郁、焦虑和淡漠）以及激越（攻击和易激惹）。这四个成分的得分与认知障碍严重程度相关。行为功能障碍、激越和情绪成分得分较高与发病年龄较低相关。行为功能障碍和情绪成分得分与性别相关。这些成分均与评估时的年龄、受教育年限或APOE ε4等位基因数量无关。
识别出四个行为成分，与之前观察到的成分相似。对这些成分的进一步分析将加深对行为症状和AD潜在病理的理解。
