Brugos B, Kiss E, Szodoray P, Szegedi G, Zeher M
Division of Clinical Immunology, 3rd Department of Internal Medicine, University of Debrecen, Debrecen, Hungary.
Scand J Immunol. 2006 Oct;64(4):433-7. doi: 10.1111/j.1365-3083.2006.01833.x.
The aim of this study was to review the development, histological type and outcome of 117 patients with lupus nephritis managed and followed by the Division of Clinical Immunology, 3rd Department of Internal Medicine, University of Debrecen, Debrecen, Hungary. The method used was a retrospective study in 117 patients with lupus nephritis followed between 1974 and 2004. The average occurrence of lupus nephritis was 3 (women) and 4.4 (men) years later after the diagnosis of systemic lupus erythematosus, 43 (46.2%) patients had class IV lupus nephritis. The initial therapy was intravenous cyclophosphamide treatment for 6 months in 37 (31.6%) patients. End-stage renal disease had developed in nine (7.6%) patients. The 5-year survival rate was 99.1%. Despite the well-known and proved risk factors like hypertension, high serum creatinine, renal failure at onset or membranous glomerulonephritis, the outcome of the disease in our patient population was more favourable than one would expect according to the data available in the literature. The authors would like to draw attention to the importance of systematic care of patients with systemic lupus erythematosus, which may lead to a better clinical outcome.
本研究旨在回顾匈牙利德布勒森大学内科第三系临床免疫学部门管理并随访的117例狼疮性肾炎患者的病情发展、组织学类型及预后情况。采用的方法是对1974年至2004年间随访的117例狼疮性肾炎患者进行回顾性研究。狼疮性肾炎平均在系统性红斑狼疮诊断后3年（女性）和4.4年（男性）出现，43例（46.2%）患者为IV级狼疮性肾炎。37例（31.6%）患者初始治疗为静脉注射环磷酰胺6个月。9例（7.6%）患者发展为终末期肾病。5年生存率为99.1%。尽管存在诸如高血压、高血清肌酐、起病时肾衰竭或膜性肾小球肾炎等众所周知且已证实的危险因素，但根据文献中的现有数据，我们患者群体中该疾病的预后比预期更为良好。作者希望提请注意系统性红斑狼疮患者系统护理的重要性，这可能会带来更好的临床结果。
