Ogretmen Besim
Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, USA.
FEBS Lett. 2006 Oct 9;580(23):5467-76. doi: 10.1016/j.febslet.2006.08.052. Epub 2006 Sep 5.
Sphingolipids are known to play important roles in the regulation of cell proliferation, response to chemotherapeutic agents, and/or prevention of cancer. Recently, significant progress has been made in the identification of the enzymes and their biochemical functions involved in sphingolipid metabolism. In addition, development of new techniques for the quantitative analysis of sphingolipids at their physiological levels has facilitated studies to examine distinct functions of these bioactive sphingolipids in cancer pathogenesis and therapy. This review will focus on the recent developments regarding the roles of bioactive sphingolipids in the regulation of cell growth/proliferation, and anti-cancer therapeutics.
已知鞘脂在细胞增殖调节、对化疗药物的反应和/或癌症预防中发挥重要作用。最近，在鉴定参与鞘脂代谢的酶及其生化功能方面取得了重大进展。此外，用于在生理水平上对鞘脂进行定量分析的新技术的发展，促进了对这些生物活性鞘脂在癌症发病机制和治疗中的不同功能的研究。本综述将聚焦于生物活性鞘脂在细胞生长/增殖调节和抗癌治疗方面作用的最新进展。
