Ragni G, Anselmino M, Nicolosi A E, Brambilla M E, Calanna G, Somigliana E
Infertility Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
Hum Reprod. 2007 Jan;22(1):210-4. doi: 10.1093/humrep/del362. Epub 2006 Sep 12.
Although follicular vascularity has been shown to be a good indicator of oocyte quality in IVF, scant evidence is currently available on the predictive value of this variable in terms of pregnancy rate during controlled ovarian stimulation (COS) and intrauterine insemination (IUI) cycles.
Three-hundred and eighteen patients who had received mild COS underwent transvaginal ultrasound scan before performing the IUI. Using power Doppler imaging, vascularity of follicles with a mean diameter > or =16 mm was graded into a three grades according to the circumference of the follicle in which flow was identified. When more than one follicle was observed, grading was performed for all of them, and the highest vascularity grade was recorded.
Clinical pregnancy rate (number/total) in the low-, medium- and high-grade vascularity groups was 14.1% (14/99), 10.0% (10/100) and 11.8% (14/119), respectively (P = 0.66). Similar results were observed when only monofollicular cycles were considered.
Follicular vascularity does not predict the chance of pregnancy in women undergoing mild COS and IUI cycles.
尽管卵泡血管生成已被证明是体外受精中卵母细胞质量的良好指标，但目前关于该变量在控制性卵巢刺激（COS）和宫内人工授精（IUI）周期中对妊娠率的预测价值的证据很少。
318例接受轻度COS的患者在进行IUI前接受经阴道超声扫描。使用能量多普勒成像，根据识别到血流的卵泡周长，将平均直径≥16 mm的卵泡血管生成分为三个等级。当观察到多个卵泡时，对所有卵泡进行分级，并记录最高血管生成等级。
低、中、高等级血管生成组的临床妊娠率（例数/总数）分别为14.1%（14/99）、10.0%（10/100）和11.8%（14/119）（P = 0.66）。仅考虑单卵泡周期时观察到类似结果。
卵泡血管生成不能预测接受轻度COS和IUI周期的女性的妊娠机会。
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