Urso G, Interlandi D, Puglisi M, Abate G, Bertino G, Raciti C, Sciacca C, Bruno M, Panarello A, Di Prima P, La Rosa G
Emergency and Internal Medicine Unit, Department of Internal Medicine and Systemic Pathologies, S. Marta Villermosa Hospital University of Catania, Catania, Italy.
Minerva Gastroenterol Dietol. 2006 Sep;52(3):303-8.
Portal hypertensive gastropathy (PHG) defines a pathological endoscopic picture characterized by the presence of alterations of the gastric mucosa found in patients with hepatopathy associated to an initial or evident portal hypertension. Gastropathy appears with two forms of different seriousness: the mild form, characterized by diffused congestion, petechiae of gastric mucosa (scarlatina type rash) and by the presence of typical hyperemic and edematous polygonal areas, delimited by a thin snake skin reticulation. In the severe form, together with such aspects, mucosal erosion, red spots, or a diffused hemorrhagic gastropathy are added. The pre-eminent pathogenetic element of such lesions seems to be the pathological increase of the portal pressure. The role of the Helicobacter pylori (H. pylori) in the development of these alterations, in terms of prevalence of infection in hepatopathic subjects, is still controversial. The authors have performed a research to verify if the H. pylori infection is correlated to the presence and/or to the gravity of PHG.
One-hundred and nine patients, all suffering from hepatitis C virus (HCV)-correlated liver cirrhosis, with clinical and/or instrumental signs of portal hypertension have been analysed.
The histological prevalence of the infection from H. pylori in our statistical analysis was of 23.8% (26/109 patients).
The H. pylori infection appears to be not significant for the determination and the preservation of PHG.
门脉高压性胃病（PHG）定义了一种病理性内镜表现，其特征为在与初始或明显门脉高压相关的肝病患者中发现胃黏膜改变。胃病有两种不同严重程度的形式：轻度形式，其特征为胃黏膜弥漫性充血、瘀点（猩红热样皮疹）以及存在典型的充血和水肿多边形区域，由细蛇皮样网状结构界定。在严重形式中，除了这些表现外，还会出现黏膜糜烂、红斑或弥漫性出血性胃病。这些病变的主要致病因素似乎是门脉压力的病理性升高。幽门螺杆菌（H. pylori）在这些改变的发生发展中所起的作用，就肝病患者中的感染率而言，仍存在争议。作者进行了一项研究，以验证H. pylori感染是否与PHG的存在和/或严重程度相关。
分析了109例均患有丙型肝炎病毒（HCV）相关性肝硬化且有门脉高压临床和/或影像学征象的患者。
在我们的统计分析中，幽门螺杆菌感染的组织学发生率为23.8%（26/109例患者）。
幽门螺杆菌感染似乎对PHG的确定和维持无显著影响。
