Bahnacy A, Kupcsulik P, Elés Z S, Jàray B, Flautner L
Semmelweis Medical University, Budapest, Hungary.
Z Gastroenterol. 1997 Feb;35(2):109-12.
This study evaluates the prevalence and significance of Helicobacter pylori (H. Pylori) infection in patients with portal hypertension. 118 patients were selected, i. e. 90 patients with portal hypertension (66 males, 24 females, mean age 49.1 +/- 2.1 years) and 28 noncirrhotic patients with nonulcerative dyspepsia as a control group (twelve males, 16 females, mean age 47.6 +/- 2.8 years). In all patients diagnostic upper endoscopy was performed and gastric biopsies were taken for histological examination and diagnosis of H. pylori infection. Of the portal hypertensive patients, 42 patients (47%) had congestive gastropathy, eleven (26%) of whom were positive for H. pylori infection and 48 (53%) did not have gastropathy, twelve (25%) of whom were positive for H. pylori infection. In the control group, 15 of 28 (54%) were positive for H. pylori infection. H. pylori was found less frequently in congestive gastropathy patients than in the control group. We found also that the presence and severity of congestive gastropathy is independent of the H. pylori status. We conclude that the role of H. pylori infection in the pathogenesis of congestive gastropathy seems to be unlikely and we suggest that there is no need for its routine eradication in cirrhotic patients.
本研究评估幽门螺杆菌（H. Pylori）感染在门静脉高压患者中的患病率及意义。选取了118例患者，即90例门静脉高压患者（男66例，女24例，平均年龄49.1±2.1岁）和28例非肝硬化非溃疡性消化不良患者作为对照组（男12例，女16例，平均年龄47.6±2.8岁）。对所有患者均进行了诊断性上消化道内镜检查，并取胃活检组织进行组织学检查及幽门螺杆菌感染诊断。在门静脉高压患者中，42例（47%）患有充血性胃病，其中11例（26%）幽门螺杆菌感染阳性，48例（53%）未患胃病，其中12例（25%）幽门螺杆菌感染阳性。在对照组中，28例中有15例（54%）幽门螺杆菌感染阳性。充血性胃病患者中幽门螺杆菌的检出率低于对照组。我们还发现充血性胃病的存在及严重程度与幽门螺杆菌感染状况无关。我们得出结论，幽门螺杆菌感染在充血性胃病发病机制中的作用似乎不大，并且我们建议肝硬化患者无需常规根除幽门螺杆菌。
