Dai L, Wu X
Second Affiliated Hospital, Chongqing Department of Gastroenterology Medical University.
Zhonghua Gan Zang Bing Za Zhi. 1999 Mar;7(1):22-3.
This study evaluates the prevalence and significance of Helicobacter pylori(H. pylori) infection in patients with portal hypertension.
177 patients were selected. Among whom, 135 patients with portal hypertension and 42 noncirrhotic patients with nonulcerative dyspepsia as a control group. In all patients diagnostic upper endoscopy was performed and gastric biopsies were taken for histological examination and diagnosis of H. pylori infection.
Of the portal hypertensive patients, 63 patients had congestive gastropathy, 17(27%) of whom were positive for H. pylori infection and 72 patients did not have gastropathy, 18(25%) of whom were positive for H. pylori infection. In the control group 23 of 42(55%) were positive for H. pylori infection. H. pylori was found less frequently in congestive gastropathy patients than in the control group. We also found that the presence and severity of congestive gastropathy is independent of the H. pylori status.
The role of H. pylori infection in the pathogenesis of congestive gastropathy seems to be unlikely and we suggest that there is no need for its routine eradication in cirrhotic patients.
本研究评估幽门螺杆菌（H. pylori）感染在门静脉高压患者中的患病率及意义。
选取177例患者。其中，135例门静脉高压患者和42例非肝硬化非溃疡性消化不良患者作为对照组。对所有患者进行诊断性上消化道内镜检查，并取胃组织活检进行组织学检查及幽门螺杆菌感染诊断。
在门静脉高压患者中，63例患有充血性胃病，其中17例（27%）幽门螺杆菌感染呈阳性；72例未患胃病，其中18例（25%）幽门螺杆菌感染呈阳性。对照组42例中有23例（55%）幽门螺杆菌感染呈阳性。充血性胃病患者中幽门螺杆菌感染率低于对照组。我们还发现充血性胃病的存在及严重程度与幽门螺杆菌感染状态无关。
幽门螺杆菌感染在充血性胃病发病机制中的作用似乎不大，我们建议肝硬化患者无需常规根除幽门螺杆菌。
