Angata Takashi
Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki, Japan.
Mol Divers. 2006 Nov;10(4):555-66. doi: 10.1007/s11030-006-9029-1.
Sialic acids are a family of acidic sugars with a 9-carbon backbone, prominently expressed in animals of deuterostome lineage. Siglecs are the largest family of vertebrate endogenous receptors that recognize glycoconjugates containing sialic acids. Although a few Siglecs are well-conserved throughout vertebrate evolution and show similar binding preference regardless of the species of origin, most others, particularly the CD33-related subfamily of Siglecs, show marked inter-species differences in repertoire, sequence, and binding preference. The diversification of CD33-related Siglecs may be driven by direct competition against pathogens, and/or by necessity to catch up with the changing landscape of endogenous glycans, which may in turn be changing to escape exploitation by other pathogens.
唾液酸是一类具有9碳骨架的酸性糖，在后口动物谱系的动物中显著表达。唾液酸结合免疫球蛋白样凝集素（Siglecs）是脊椎动物内源性受体中最大的家族，可识别含有唾液酸的糖缀合物。尽管少数Siglecs在整个脊椎动物进化过程中高度保守，且无论其来源物种如何，都表现出相似的结合偏好，但大多数其他Siglecs，特别是Siglecs的CD33相关亚家族，在组成、序列和结合偏好方面表现出明显的种间差异。CD33相关Siglecs的多样化可能是由与病原体的直接竞争驱动的，和/或由跟上内源性聚糖不断变化的格局的必要性驱动的，而内源性聚糖的变化反过来可能是为了逃避其他病原体的利用。
