Altman H J, Normile H J, Galloway M P, Ramirez A, Azmitia E C
Lafayette Clinic, Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48207.
Brain Res. 1990 Jun 4;518(1-2):61-6. doi: 10.1016/0006-8993(90)90954-a.
Learning in rats trained in the Stone 14-unit T-maze, a complex, positively reinforced spatial discrimination task was assessed following cytotoxic (5,7-dihydroxytryptamine; 5,7-DHT) deafferentation of the serotonergic inputs to the hippocampus. Serotonergic deafferentation was accomplished by infusing the cytotoxin in to the fornix-fimbria/cingulum bundle. Lesioned rats reached criterion (i.e. learned) in significantly fewer trials and made significantly fewer errors throughout training than either vehicle-injected or sham-operated controls. This represents the first time that the effects of selective chronic destruction of serotonergic inputs to the hippocampus have been investigated. The present results provide, therefore, evidence in support of a neuromodulatory role for serotonin (5-HT) within the rat hippocampus in the mediation of the processes underlying learning and memory for this task. Other studies are, therefore, warranted in order to determine whether hippocampal 5-HT also plays a role in the mediation of the processes underlying learning and memory in other types of tasks.
在经过训练的大鼠中进行学习研究，这些大鼠被训练于斯通14单元T型迷宫中，这是一项复杂的、正强化的空间辨别任务。在对海马体的5-羟色胺能传入神经进行细胞毒性（5,7-二羟基色胺；5,7-DHT）去传入作用后，对该任务进行评估。通过将细胞毒素注入穹窿-海马伞/扣带束来实现5-羟色胺能去传入作用。与注射溶剂或假手术对照组相比，损伤大鼠在显著更少的试验次数中达到标准（即学会），并且在整个训练过程中犯的错误显著更少。这是首次对海马体5-羟色胺能传入神经的选择性慢性破坏的影响进行研究。因此，目前的结果为5-羟色胺（5-HT）在大鼠海马体内对该任务学习和记忆基础过程的介导中发挥神经调节作用提供了证据。因此，有必要进行其他研究，以确定海马体5-HT在其他类型任务的学习和记忆基础过程的介导中是否也发挥作用。
