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前额叶5-羟色胺耗竭会延迟逆向学习，并增加腹内侧前额叶-前额叶前肢-眶额皮质回路的θ同步性。

Prefrontal serotonin depletion delays reversal learning and increases theta synchronization of the infralimbic-prelimbic-orbitofrontal prefrontal cortex circuit.

作者信息

Estrada-Reyes Yoana, Cervantes-Alfaro José Miguel, López-Vázquez Miguel Ángel, Olvera-Cortés María Esther

机构信息

Laboratorio de Neuroplasticidad de los Procesos Cognitivos, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, Michoacán, Mexico.

Laboratorio de Neurofisiología Clínica y Experimental, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, Michoacán, Mexico.

出版信息

Front Pharmacol. 2024 Dec 3;15:1501896. doi: 10.3389/fphar.2024.1501896. eCollection 2024.

DOI:10.3389/fphar.2024.1501896
PMID:39691394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649410/
Abstract

INTRODUCTION

Prefrontal serotonin plays a role in the expression of flexible behavior during reversal learning tasks as its depletion delays reversal learning. However, the mechanisms by which serotonin modulates the prefrontal cortex functions during reversal learning remain unclear. Nevertheless, serotonin has been shown to modulate theta activity during spatial learning and memory.

METHODS

We evaluated the effects of prefrontal serotonin depletion on theta activity in the prefrontal infralimbic, prelimbic, and orbitofrontal (IL, PL, and OFC) subregions of male rats during a spatial reversal learning task in an aquatic T-maze.

RESULTS

Prefrontal serotonin depletion delayed spatial reversal learning and increased theta activity power in the PL and OFC. Furthermore, animals with serotonin depletion had increased functional coupling between the OFC and the IL and PL cortices compared with the control group.

DISCUSSION

These results indicate that serotonin regulates reversal learning through modulation of prefrontal theta activity by tuning both the power and functional synchronization of the prefrontal subregions.

摘要

引言

前额叶5-羟色胺在反转学习任务中灵活行为的表达中起作用，因为其耗竭会延迟反转学习。然而，5-羟色胺在反转学习过程中调节前额叶皮质功能的机制仍不清楚。尽管如此，5-羟色胺已被证明在空间学习和记忆过程中调节θ活动。

方法

我们在水生T迷宫的空间反转学习任务中，评估了雄性大鼠前额叶5-羟色胺耗竭对前额叶腹内侧、前边缘和眶额（IL、PL和OFC）亚区θ活动的影响。

结果

前额叶5-羟色胺耗竭延迟了空间反转学习，并增加了PL和OFC中的θ活动功率。此外，与对照组相比，5-羟色胺耗竭的动物OFC与IL和PL皮质之间的功能耦合增加。

讨论

这些结果表明，5-羟色胺通过调节前额叶θ活动来调节反转学习，调节方式包括调整前额叶亚区的功率和功能同步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/a613b6a8d59f/fphar-15-1501896-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/ac17acf98b86/fphar-15-1501896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/1c7955cce3d9/fphar-15-1501896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/04e0567a548a/fphar-15-1501896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/784b8769a3f7/fphar-15-1501896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/263be5df4dd9/fphar-15-1501896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/98ddcb365171/fphar-15-1501896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/ded357e5d063/fphar-15-1501896-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/a613b6a8d59f/fphar-15-1501896-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/ac17acf98b86/fphar-15-1501896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/1c7955cce3d9/fphar-15-1501896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/04e0567a548a/fphar-15-1501896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/784b8769a3f7/fphar-15-1501896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/263be5df4dd9/fphar-15-1501896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/98ddcb365171/fphar-15-1501896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/ded357e5d063/fphar-15-1501896-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d0/11649410/a613b6a8d59f/fphar-15-1501896-g008.jpg

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