来自越南大风子树皮的两种新酚苷及其抗炎和抗氧化活性。

Two new phenolic glycosides from the barks of Hydnocarpus annamensis and their anti-inflammatory and anti-oxidation activities.

作者信息

Shi Hai-Ming, Wen Jing, Jia Cun-Qin, Jin Wei, Zhang Xiu-Feng, Yao Zhi-Rong, Tu Peng-Fei

机构信息

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, PR China.

出版信息

Planta Med. 2006 Aug;72(10):948-50. doi: 10.1055/s-2006-946678.

DOI:10.1055/s-2006-946678

PMID:16972202

Abstract

Two new phenolic glycosides 1 and 2 were isolated from the barks of Hydnocarpus annamensis, along with eighteen known compounds. The structures of all compounds were deduced using spectroscopic methods. Anti-inflammatory and anti-oxidation activities were evaluated. Among the isolates, compounds 1, 5, 15 and 17 exhibited COX-2 inhibitory activities, with an inhibitory rate of 60.3 - 63.4 % at 10 microM. Compounds 7, 12, 13 and 20 showed anti-oxidation capacities in the DPPH free-radical assay, with a scavenging effect of 60.9 - 69.4 % at 50 microM, and 18.5 - 34.6 % at 10 microM.

摘要

从越南大风子的树皮中分离出两种新的酚苷1和2，以及十八种已知化合物。所有化合物的结构均通过光谱方法推导得出。对其抗炎和抗氧化活性进行了评估。在分离出的化合物中，化合物1、5、15和17表现出COX - 2抑制活性，在10微摩尔浓度下抑制率为60.3 - 63.4%。化合物7、12、13和20在DPPH自由基测定中显示出抗氧化能力，在50微摩尔浓度下清除率为60.9 - 69.4%，在10微摩尔浓度下为18.5 - 34.6%。