Ukiya Motohiko, Akihisa Toshihiro, Yasukawa Ken, Koike Kazuo, Takahashi Akitomo, Suzuki Takashi, Kimura Yumiko
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
J Nat Prod. 2007 May;70(5):813-6. doi: 10.1021/np078002l. Epub 2007 May 5.
Two new oleanane-type triterpene glycosides, named helianthosides 4 (4) and 5 (5), along with four known triterpene glycosides, helianthosides 1 (1), 2 (2), 3 (3), and B (6), were isolated from an n-butanol-soluble fraction of a methanol extract of sunflower (Helianthus annuus) petals. The structures of the two new compounds were determined on the basis of spectroscopic and chemical methods. Upon evaluation of compounds 1-6 for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1.7 nmol/ear) in mice, all of the compounds tested exhibited marked anti-inflammatory activity, with ID50 values in the range 65-262 nmol per ear.
从向日葵（Helianthus annuus）花瓣甲醇提取物的正丁醇可溶部分中分离出两种新的齐墩果烷型三萜糖苷，命名为向日葵苷4（4）和5（5），以及四种已知的三萜糖苷，向日葵苷1（1）、2（2）、3（3）和B（6）。通过光谱和化学方法确定了这两种新化合物的结构。在评估化合物1 - 6对小鼠12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）诱导的炎症（1.7 nmol/耳）的抑制活性时，所有测试化合物均表现出显著的抗炎活性，每耳的ID50值在65 - 262 nmol范围内。
