Inoue Tetsuro, Tanaka Eisaku, Sukuramoto Minoru, Minakuchi Masayoshi, Maeda Yuji, Maniwa Ko, Terada Kunihiko, Tanizawa Kiminobu, Hashimoto Seishu, Goto Shunsuke, Takeda Tomoshi, Okamoto Masaki, Kobashi Yoichiro, Yuba Yoshiaki, Noma Satoshi, Yoshizawa Yasuyuki, Ohtani Yoshio, Taguchi Yoshio
Department of Respiratory Medicine, Tenri Hospital.
Nihon Kokyuki Gakkai Zasshi. 2006 Aug;44(8):550-5.
We retrospectively evaluated 8 cases of bird related hypersensitivity pneumonitis in Tenri hospital, all of whom underwent surgical lung biopsy. They had a history of contacting with birds and had serological studies using lymphocyte stimulation test to pigeon serum or antibody in serum and bronchoalveolar lavage fluid to pigeon dropping extracts yielded positive results. Computed tomography revealed a radiographic pattern unlike typical UIP. The result of pathological diagnosis of surgical lung biopsy was 'others' or NSIP pattern. Only one case had pathological findings of granuloma. Four cases had an improved or stable course only offer segregation from bird antigens. The other four cases needed corticosteroids and immunosuppressants, and two of the four cases had a progressive course and died of respiratory failure.
我们回顾性评估了天理医院8例与鸟类相关的过敏性肺炎病例,所有患者均接受了外科肺活检。他们有接触鸟类的病史,并且通过淋巴细胞刺激试验对鸽血清或血清及支气管肺泡灌洗液中的鸽粪提取物抗体进行血清学研究,结果呈阳性。计算机断层扫描显示的影像学表现不同于典型的特发性肺纤维化(UIP)。外科肺活检的病理诊断结果为“其他”或非特异性间质性肺炎(NSIP)模式。只有1例有肉芽肿的病理表现。4例仅通过与鸟类抗原隔离后病情得到改善或稳定。另外4例需要使用皮质类固醇和免疫抑制剂,其中4例中有2例病情进展,死于呼吸衰竭。