Leighton B, Challiss R A, Newsholme E A
Department of Biochemistry, University of Oxford, United Kingdom.
Horm Metab Res Suppl. 1990;22:89-95.
Prostaglandins of the E series are known to increase the sensitivity of glucose uptake to insulin in isolated, incubated skeletal muscle of the rat. In the present study the relationships between changes in both insulin sensitivity and prostaglandins E2 metabolism were investigated. Chronic treatment of rats with the synthetic glucocorticoid dexamethasone causes an insulin resistant state in vivo. Also, the sensitivity of glucose metabolism to insulin from normal rats varies over a 24-h period. In both these rat models the sensitivity of glucose metabolism to insulin in isolated skeletal muscle was greatest when the content or rates of release of prostaglandin E2 were highest. These results strongly suggest that changes in PGE2 metabolism can influence the sensitivity of glucose metabolism to insulin in skeletal muscle.
已知E系列前列腺素可增强大鼠离体培养骨骼肌对胰岛素摄取葡萄糖的敏感性。在本研究中，对胰岛素敏感性变化与前列腺素E2代谢之间的关系进行了研究。用合成糖皮质激素地塞米松对大鼠进行长期治疗可在体内导致胰岛素抵抗状态。此外，正常大鼠的葡萄糖代谢对胰岛素的敏感性在24小时内会有所变化。在这两种大鼠模型中，当前列腺素E2的含量或释放速率最高时，离体骨骼肌中葡萄糖代谢对胰岛素的敏感性也最强。这些结果有力地表明，PGE2代谢的变化可影响骨骼肌中葡萄糖代谢对胰岛素的敏感性。
