钒酸盐对骨骼肌葡萄糖和蛋白质代谢的胰岛素样作用的选择性
Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle.
作者信息
Clark A S, Fagan J M, Mitch W E
出版信息
Biochem J. 1985 Nov 15;232(1):273-6. doi: 10.1042/bj2320273.
Abstract
To determine if vanadate has insulin-like actions in skeletal muscle, we measured its effects on glucose and protein metabolism in epitrochlearis muscles of rats. Compared with insulin, vanadate increased glucose uptake, glycogen synthesis and glycolysis to a lesser degree, but caused a greater stimulation of lactate and glucose oxidation. Unlike insulin, vanadate did not change either protein synthesis or degradation. These different metabolic responses could be related to the different pattern of insulin-receptor phosphorylation caused by insulin and vanadate.
摘要
为了确定钒酸盐在骨骼肌中是否具有胰岛素样作用，我们测量了其对大鼠肱三头肌中葡萄糖和蛋白质代谢的影响。与胰岛素相比，钒酸盐对葡萄糖摄取、糖原合成和糖酵解的促进作用较小，但对乳酸和葡萄糖氧化的刺激作用更强。与胰岛素不同，钒酸盐对蛋白质合成或降解均无影响。这些不同的代谢反应可能与胰岛素和钒酸盐引起的胰岛素受体磷酸化模式不同有关。
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