Qiu Chunfang, Saito Shigeru, Sakai Masatoshi, Ogawa Kazuyuki, Nagata Kinya, Williams Michelle A
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA.
Clin Biochem. 2006 Oct;39(10):1016-21. doi: 10.1016/j.clinbiochem.2006.07.008. Epub 2006 Aug 16.
Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women.
50 preeclampsia cases and 50 normotensive controls (USA) were studied. Plasma granulysin at delivery was determined using enzyme immunoassay. Logistic regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Granulysin were elevated in preeclampsia cases compared with controls (3.01+/-0.18 vs. 2.22+/-0.14 ng/mL, p<0.01). After adjusting for age, body-mass-index and race, women with higher granulysin concentrations (> or =1.89 ng/mL) experienced a 2.9-fold (95%CI 1.1-7.8) increased preeclampsia risk compared with women with lower granulysin (<1.89 ng/mL).
These data offer further evidence of a predominant Th1 immune status associated with preeclampsia. Prospective studies are needed to determine whether granulysin is elevated early in pregnancy.
流行病学、临床及组织学数据表明，先兆子痫与移植物抗宿主排斥反应之间存在有趣的相似之处。颗粒溶素是一种整体细胞免疫的新型生物标志物，由与移植物抗宿主排斥反应相关的自然杀伤细胞和细胞毒性T淋巴细胞分泌。日本先兆子痫女性的血浆颗粒溶素水平升高。
对50例先兆子痫病例和50例血压正常的对照者（美国）进行研究。采用酶免疫测定法测定分娩时的血浆颗粒溶素水平。使用逻辑回归程序估计比值比（OR）和95%置信区间（CI）。
与对照组相比，先兆子痫病例的颗粒溶素水平升高（3.01±0.18对2.22±0.14 ng/mL，p<0.01）。在对年龄、体重指数和种族进行校正后，颗粒溶素浓度较高（≥1.89 ng/mL）的女性与颗粒溶素浓度较低（<1.89 ng/mL）的女性相比，先兆子痫风险增加2.9倍（95%CI 1.1 - 7.8）。
这些数据进一步证明了与先兆子痫相关的主要Th1免疫状态。需要进行前瞻性研究以确定妊娠早期颗粒溶素水平是否升高。
