Choudhry Shweta, Burchard Esteban González, Borrell Luisa N, Tang Hua, Gomez Ivan, Naqvi Mariam, Nazario Sylvette, Torres Alphonso, Casal Jesus, Martinez-Cruzado Juan Carlos, Ziv Elad, Avila Pedro C, Rodriguez-Cintron William, Risch Neil J
University of California, San Francisco, San Francisco, CA 94143-2911, USA.
Am J Respir Crit Care Med. 2006 Nov 15;174(10):1088-93. doi: 10.1164/rccm.200605-596OC. Epub 2006 Sep 14.
Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, no such relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry.
We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median family income. Analyses of SES were based on the SES of the clinic site from which the subjects were recruited and on a subset of individuals on whom home address-based SES was available.
In the two (independent) analyses, we found a significant interaction between SES, ancestry, and asthma disease status. At lower SES, European ancestry was associated with increased risk of asthma, whereas African ancestry was associated with decreased risk. The opposite was true for their higher SES counterparts.
The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry.
波多黎各人是非洲、欧洲和美洲原住民血统的混合人群，其哮喘患病率、发病率和死亡率在美国所有人群中最高。尽管社会经济地位（SES）在大多数人群中与哮喘发病率呈负相关，但在波多黎各人中尚未发现这种关系。我们假设，在这个混合人群中，SES与哮喘之间的关联可能会与遗传血统相互作用。
我们分析了从波多黎各六个不同招募中心招募的135名患有哮喘的波多黎各受试者和156名对照受试者。使用44个祖先信息标记估计每个受试者的个体血统。SES根据人口普查区的家庭收入中位数进行分配。SES分析基于受试者招募诊所所在地的SES以及可获得基于家庭住址的SES的个体子集。
在两项（独立）分析中，我们发现SES、血统和哮喘疾病状态之间存在显著相互作用。在较低的SES水平下，欧洲血统与哮喘风险增加相关，而非洲血统与风险降低相关。在较高SES水平的人群中情况则相反。
观察到的相互作用可能有助于解释波多黎各人哮喘风险的独特模式，以及之前研究在未考虑不同血统比例时未观察到与SES的关联。
