Afshar Majid, Wu Donghong, Durazo-Arvizu Ramon, Aguilar Frank G, Kalhan Ravi, Davis Sonia M, Kaplan Robert, Klein Oana L, Mende Eliana P, Pattany Maria S, Daviglus Martha L
Division of Pulmonary and Critical Care, Loyola University Stritch School of Medicine.
Institute for Minority Health Research, University of Illinois at Chicago.
J Pulm Respir Med. 2017 Aug;7(4). doi: 10.4172/2161-105X.1000419. Epub 2017 Aug 31.
Substantial variation in the prevalences of obstructive lung disease exist between Hispanic/Latino heritage groups. Experimental studies have posited biological mechanisms linking serum lipids and lipid-lowering medications with obstructive lung disease. The aim of this study is to examine the associations of serum lipid levels with the prevalences of asthma and chronic obstructive pulmonary disease in the Hispanic Community Health Study/Study of Latinos and how these associations vary by Hispanic/Latino heritage group.
The Hispanic Community Health Study/Study of Latinos is a population-based probability sample of 16,415 self-identified Hispanic/Latino persons aged 18-74 years recruited between 2008 and 2011 from randomly selected households in four US field centers. The baseline clinical examination included comprehensive biological testing (fasting serum lipid levels), behavioral and socio-demographic assessments, medication inventory including inhalers, and respiratory data including questionnaires for asthma and standardized spirometry with post-bronchodilator measures for identification of obstructive lung disease.
Hispanic/Latinos with current asthma had lower age- and statin-use-adjusted mean serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels than their non-asthmatic counterparts. In analysis adjusted for age plus gender, ethnicity, cigarette smoking, alcohol intake, body mass index, lipid/cholesterol-lowering medications, age at immigration, health insurance status, and use of oral corticosteroids, increasing serum levels of total cholesterol and low-density lipoprotein cholesterol were associated with lower odds of current asthma in the estimated population. Unlike asthma, Hispanic/Latinos with chronic obstructive pulmonary disease had lower mean high-density lipoprotein than their non- chronic obstructive pulmonary disease counterparts. In the fully adjusted analysis no significant associations were found between lipid levels and prevalent chronic obstructive pulmonary disease.
We showed a modest inverse relationship between serum lipid levels and current asthma. These results highlight some important differences in Hispanics/Latinos and certain serum lipids may be factors or markers of obstructive lung disease.
西班牙裔/拉丁裔群体中阻塞性肺病的患病率存在显著差异。实验研究提出了将血清脂质和降脂药物与阻塞性肺病联系起来的生物学机制。本研究的目的是在西班牙裔社区健康研究/拉丁裔研究中，检验血清脂质水平与哮喘和慢性阻塞性肺疾病患病率之间的关联，以及这些关联如何因西班牙裔/拉丁裔群体而异。
西班牙裔社区健康研究/拉丁裔研究是一项基于人群的概率样本研究，从2008年至2011年期间，在美国四个实地中心随机抽取的家庭中招募了16415名年龄在18 - 74岁之间、自我认定为西班牙裔/拉丁裔的人。基线临床检查包括全面的生物学检测（空腹血清脂质水平）、行为和社会人口学评估、包括吸入器在内的药物清单，以及呼吸数据，包括哮喘问卷和用于识别阻塞性肺病的支气管扩张剂后标准化肺活量测定。
患有当前哮喘的西班牙裔/拉丁裔人群，其年龄和他汀类药物使用调整后的平均血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平低于非哮喘患者。在对年龄、性别、种族、吸烟、饮酒、体重指数、降脂药物、移民年龄、健康保险状况和口服皮质类固醇使用情况进行调整的分析中，估计人群中血清总胆固醇和低密度脂蛋白胆固醇水平升高与当前哮喘的较低几率相关。与哮喘不同，患有慢性阻塞性肺疾病的西班牙裔/拉丁裔人群的平均高密度脂蛋白低于非慢性阻塞性肺疾病患者。在完全调整分析中，未发现脂质水平与慢性阻塞性肺疾病患病率之间存在显著关联。
我们发现血清脂质水平与当前哮喘之间存在适度的负相关关系。这些结果凸显了西班牙裔/拉丁裔人群中的一些重要差异，某些血清脂质可能是阻塞性肺病的因素或标志物。
