Ishiyama Gail, López Ivan A, Ishiyama Akira
Department of Neurology, Division of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles 90095, USA.
Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):332-6. doi: 10.1097/01.moo.0000244191.51560.22.
Review of the role of aquaporins in inner ear homeostasis and potential role in the pathogenesis of Meniere's disease.
Recent findings include the immunolocalization of aquaporins in the inner ear of mouse, rat, and human to cell types that are likely to undergo high ionic perturbances (e.g. potassium flux) and to putative areas of endolymph resorption or cycling.
The expression of aquaporins and related proteins in the human cochlea and vestibular periphery resembles the distribution found in animal models, suggesting a critical role of aquaporins in inner ear water homeostasis and their potential role in the pathogenesis of Meniere's disease.
综述水通道蛋白在内耳内环境稳态中的作用以及在梅尼埃病发病机制中的潜在作用。
最新发现包括水通道蛋白在小鼠、大鼠和人类内耳中的免疫定位，这些细胞类型可能经历高离子扰动（如钾离子通量）以及内淋巴吸收或循环的假定区域。
水通道蛋白及相关蛋白在人类耳蜗和前庭外周的表达类似于在动物模型中发现的分布，表明水通道蛋白在内耳水稳态中起关键作用，及其在梅尼埃病发病机制中的潜在作用。
